Genetic characterization of skull base chondrosarcomas

Chondrosarcomas of the skull base and temporal bone.

OBJECTIVE To evaluate the clinical presentation and outcomes of treatment for patients with chondrosarcomas involving the skull base and temporal bone. STUDY DESIGN Retrospective review. SETTING Tertiary medical centre. PATIENTS Cases of histologically confirmed chondrosarcoma involving the skull base and temporal bones. INTERVENTION Surgery. MAIN OUTCOME MEASURES Demographic features...

Proton radiation therapy for chordomas and chondrosarcomas of the skull base.

OBJECT Local tumor control, patient survival, and treatment failure outcomes were analyzed to assess treatment efficacy in 58 patients in whom fractionated proton radiation therapy (RT) was administered for skull base chordomas and chondrosarcomas. METHODS Between March 1992 and January 1998, a total of 58 patients who could be evaluated were treated for skull base tumors, 33 for chordoma and...

Differentiation of skull base chordomas from chondrosarcomas by diffusion-weighted MRI.

Genomic and transcriptomic characterization of skull base chordoma

Skull base chordoma is a primary rare malignant bone-origin tumor showing relatively slow growth pattern and locally destructive lesions, which can only be characterized by histologic components. There is no available prognostic or therapeutic biomarker to predict clinical outcome or treatment response and the molecular mechanisms underlying chordoma development still remain unexplored. Therefo...

Fungal infection of the sinus and anterior skull base

  Abstract   Background: Invasive fungal infection is an opportunistic infection caused commonly   by mucoraccae and aspergillus. It mostly occurs in patients with underlying disease.   Since it has a high mortality and morbidity rate, considering a treatment strategy seems   necessary.   Objective: Since there has not been a clear protocol for treating these patients, we decided   to establish...